Vitamin D comparison

Vitamin D2 vs Vitamin D3

Sources, vegan status, how well each raises vitamin D levels, and how to read the label.

Last reviewed September 28, 20262 referencesNo universal winner
Quick answer

Both forms raise vitamin D levels. In a 2012 meta-analysis of randomized trials, D3 raised blood 25-hydroxyvitamin D more effectively than D2, especially with large, infrequent doses. D2 is vegan by source; most D3 comes from lanolin, though vegan D3 from lichen is available. Labels list micrograms — 25 mcg = 1,000 IU.

Vitamin D2 vs Vitamin D3
CompareD2D3
Chemical nameErgocalciferolCholecalciferol
Typical sourceUV-exposed yeast or fungiLanolin (sheep’s wool); lichen for vegan
VeganYes (check capsule)Only if from lichen
Raising blood 25(OH)DPublished researchEffectiveMore effective in meta-analysis
Common inSome prescriptions, fortified foodsMost over-the-counter supplements
Label unitsmcg (IU optional)mcg (IU optional)
Cost per 1,000 IU (demo)SuppScout calculationBased on fictional demonstration listingsNo priced products yet$0.03–$0.09 (demo)

Rows marked with a source type show where the information comes from. See how SuppScout compares.

Who might look at each

Vitamin D2

  • People who need a vegan product and prefer D2

Vitamin D3

  • People comparing the form with more comparative research

These describe common reasons people consider each option — not a recommendation. There’s no universal winner.

Vitamin D2 and Vitamin D3, explained

Vitamin D2

The fungal/yeast form of vitamin D. D2 overview.

Vitamin D3

The form the skin makes from sunlight. D3 overview.

Key differences

  • D3 raised blood levels more in pooled trials.
  • D2 is vegan by default; D3 usually isn’t.
  • D3 dominates over-the-counter products.

Similarities

  • Both raise vitamin D status.
  • Same RDA and upper limit apply.
  • Same label units.
Published research

Research overview

Tripkovic et al. (2012) pooled randomized trials and found D3 more efficacious at raising serum 25(OH)D than D2, with the difference most apparent for bolus doses. With daily dosing the difference was smaller. The NIH notes both forms are well absorbed.[1][2]

How to read product labels

  • Convert units: mcg × 40 = IU.
  • Look for the source (lanolin vs lichen) if vegan status matters.
  • Add up vitamin D across all products you take.

Full guide: how to read a supplement label

Products containing each

Vitamin D2

Plainlabel Vitamin D2 1,000 IU

Plainlabel Nutrition · Demo
Primary ingredient
Vitamin D2 (Ergocalciferol)
Per serving
25 mcg (1,000 IU) vitamin D
Servings
120
Format
Tablets
Price
Unavailable
Per serving cost
$0.08
Not verified
Vitamin D2 overview →

Vitamin D3

Primary ingredient
Vitamin D3 (Cholecalciferol)
Per serving
25 mcg (1,000 IU) vitamin D
Servings
30
Format
Gummies
Price
Not available
Per serving cost
—
Not verified
Primary ingredient
Vitamin D3 (Cholecalciferol)
Per serving
25 mcg (1,000 IU) vitamin D
Servings
365
Format
Softgels
Price
$11.99*
Per serving cost
$0.03
Not verified

Verdana Botanicals Vegan D3 2,000 IU

Verdana Botanicals · Demo
Primary ingredient
Vitamin D3 (Cholecalciferol)
Per serving
50 mcg (2,000 IU) vitamin D
Servings
90
Format
Capsules
Price
$16.99*
Per serving cost
$0.19
Not verified
Vitamin D3 overview →

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Frequently asked questions

Is 1,000 IU the same as 25 mcg?

Yes. 1 mcg of vitamin D = 40 IU.

References

  1. Tripkovic L, Lambert H, Hart K, et al. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. American Journal of Clinical Nutrition 95(6). doi:10.3945/ajcn.111.031070Meta-analysis
  2. Vitamin D: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. ods.od.nih.govGovernment

SuppScout links to primary and authoritative sources wherever possible. See our editorial policy for how sources are selected and how corrections are handled.

This page is educational and is not medical advice. Talk to a healthcare professional before starting a supplement, especially if you have a medical condition, take medications, or are pregnant or breastfeeding.